Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity
Giżyńska M, Witkowska J, Karpowicz P, Rostankowski R, Chocron ES, Pickering AM, Osmulski P, Gaczynska M, Jankowska E.
J Med Chem. 2019 Jan 10;62(1):359-370. doi: 10.1021/acs.jmedchem.8b01025. Epub 2018 Dec 3. PMID: 30452262; PMCID: PMC6796967.
Munkácsy E, Chocron ES, Quintanilla L, Gendron CM, Pletcher SD, Pickering AM
Aging Cell. 2019 Oct;18(5):e13005. doi: 10.1111/acel.13005. Epub 2019 Jul 23. PMID: 31334599; PMCID: PMC6718538.
New Peptide-Based Pharmacophore Activates 20S Proteasome.
Osmulski PA, Karpowicz P, Jankowska E, Bohmann J, Pickering AM, Gaczyńska M.
Molecules. 2020 Mar 22;25(6):1439. doi: 10.3390/molecules25061439. PMID: 32235805; PMCID: PMC7145288.
Chocron ES, Munkácsy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM.
Science Advances. 2022 Jun 10;8(23):eabk2252. doi: 10.1126/sciadv.abk2252. Epub 2022 Jun 8. PMID: 35675410; PMCID: PMC9177073.
Proteasome Augmentation Mitigates Age-Related Cognitive
Decline in Mice
Parker D, Davidson K, Osmulski PA, Gaczynska M, Pickering AM.
Patent Application: Peptide-based compositions and methods for treating alzheimer’s disease
Inventorsz: Pawel A. Osmulski, Maria Gaczynska, Andrew Pickering
Przemyslaw Karpowicz, Elzbieta Jankowska
International Publication Number: WO2021050890A1 WIPO (PCT) filed March 18 2021