Targeting Proteostasis as a breakthrough in Alzheimer’s disease therapy
The Growing Challenge of Alzheimer’s Disease
Alzheimer’s disease affects over six million Americans, and this number is expected to rise as the population ages.
Unfortunately, current treatments provide only limited benefits, especially in the later stages of the disease.
A New Approach: Protecting the Brain’s Waste Disposal System
The proteasome is a key system that helps brain cells clear out harmful proteins, but its function declines with age and is further impaired in Alzheimer’s.
By restoring proteasome activity, we aim to protect brain cells, improve memory function, and slow disease progression.
Innovative Therapeutics: Targeting Proteasome Dysfunction
Our team has developed novel compounds that not only activate the proteasome but also protect it from damage caused by toxic Alzheimer’s proteins.
These drug candidates have shown promising results in animal models, offering hope for a new and effective treatment strategy.
